Novel repeated intralesional treatment using thawed pooled allogeneic equine CB-MSC results in positive clinical outcomes

Equine multi-potent mesenchymal stromal cells (MSCs) show potential for promoting tendon repair. This study aims to evaluate the efficacy of repeated intralesional injections of allogeneic pooled umbilical cord blood-derived MSCs

Cross-sectional ultrasound images of the SDF/DDFT

for superficial digital flexor tendinopathy in racehorses. The objective was to assess physical, ultrasonographic, and lameness outcomes over a one-year period and determine the horses' ability to return to full work. These findings have implications for improving the man-agement and recovery of tendinopathies in equine athletes. We hypothesized that repeated treatment with pooled frozen CB-MSCs for naturally occurring SDF tendinopathies in horses will enable them to return to athletic activity, and that repeated treatments will not be associated with adverse reactions. In this study, CB-MSC treatment enabled three horses to return to racing and one to perform as a hunter-jumper. Although repeat intralesional CB- MSC injections did not cause serious adverse reactions, a statistically significant transient inflammatory response was observed at the injection site. This inflammation resolved with phenylbutazone and icing, without further treatment beyond the study protocol Read here the complete report, published in Equine Vet Educ. 2025;00:1–12.